[DPro10] Dynorphin A (1-11), porcine hydrochloride_product_DataBase

Bioactivity	[DPro10] Dynorphin A (1-11), porcine hydrochloride, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine hydrochloride has analgesic property[1][2].
Invitro	[DPro10] Dynorphin A (1-11), porcine has inhibition of adenylyl cyclase activity in k-opioid receptor-expressing CHO cells with an IC50 value of 0.12 nM[1]. 0 --> [DPro10] Dynorphin A (1-11), porcine hydrochloride 相关抗体:
In Vivo	[DPro10] Dynorphin A (1-11), porcine (ICV) has analgesic effects involving thermal cutaneous (tail-flick) and chemical visceral (AcOH-induced writhing) stimuli, in which mu and kappa receptors are known to be activated differentially[2].
Name	[DPro10] Dynorphin A (1-11), porcine hydrochloride
Sequence	Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-{d-Pro}-Lys
Shortening	YGGFLRRIR-{d-Pro}-K
Formula	C63H103N21O13.xHCl
Molar Mass	1362.62 (free acid)
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Soderstrom K, et, al. N-alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are high affinity partial agonists at the cloned rat kappa-opioid receptor. Eur J Pharmacol. 1997 Nov 5;338(2):191-7. [2]. Gairin JE, et, al. [D-Pro10]-dynorphin(1-11) is a kappa-selective opioid analgesic in mice. J Pharmacol Exp Ther. 1988 Jun;245(3):995-1001.

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